Tumor Tips

Tumor Tip of the Week-05-23-2025 Neoadjuvant or Not

05-23-2025

Neoadjuvant or Not

Scenario:

Scans: 3-1-2025 CT Ab/Pelvis: 7.5cm bladder wall thickening/mass lower right lateral aspect bladder, *no lymphadenopathy or distant mets notedTumor Size Summary 070   STORE/SEER-Record the size from the op note over the size on the imaging [use size from TURB]   *Substantiates coding of cN0 cM0   03-26-2025 Surgery Code A270 SEER Appendix C: SEER Note: Code TURB as A270]
Operative Text & Path: 3-26-2025 TURB: 7cm large bladder tumor over right lateral bladder wall extending to anterior bladder wall and to lateral aspect of right trigone. Transurethral resection/debulking of large bladder tumor performed with resection clinically into muscle proper. Path: invasive poorly differentiated urothelial carcinoma, invades muscle propria
Stage: Muscle Invasive Bladder Cancer, no regional lymph node mets or distant mets noted on scansEOD Primary Tumor 370 Muscle (muscularis propria) invaded, NOS of bladder only *Cannot assign codes 200,250,300,350 based on TURB-those codes require a cystectomy.   [Our patient did have a Cystectomy after neoadjuvant therapy and there was no residual, so we will base the depth of invasion on the TURB, assign code 370.]   EOD Regional Nodes 000   EOD Mets 00   Summary Stage 1 Localized   Clinical Stage (Based on TURB & Scans prior) cT2 cN0 cM0 Stage 2 *Cannot assign a cT2a or cT2b based on TURB-a cystectomy must be performed to make that determination. 
Chemo: 4-29-2025 to 06-16-2025 Neoadjuvant Chemotherapy w/ DDMVAC (dose-dense methotrexate, vinblastine, doxorubicin, cisplatin)04-29-2025 Chemo Code 03   DD means Dose Dense, look up regimen MVAC in SEER*RX for the drugs used and instructions on how to code
Operative Text & Path: 07-18-2025 Radical Cystoprostatectomy and bilateral pelvic lymph node dissection & ileal conduit-extravesical disease not noted, no mets disease Path: No residual, 4 left pelvic lymph nodes (-) 4 right pelvic lymph nodes (-)07-18-2025 Surgery Code A710   07-18-2025 [SEER Note: Use code A710 for Cystoprostatectomy]

Question: Is the patient eligible for Post Therapy Path (yp) Stage?

  • Yes
  • No

Answer & Rationale: Yes, this patient is eligible for Post Therapy yp Stage.

Although the TURB was coded as a surgical procedure code of A270, a TURB is not considered definitive treatment in this case.  After TURB, the patient was treated with neoadjuvant chemotherapy and subsequent Radical Cystoprostatectomy.  The yp Stage will be assigned ypT0 {no evidence of any residual primary tumor} ypN0 {8 nodes-} cM0 {No evidence of distant mets on scans} Stage 99.

AJCC 8th Edition

Chapter 1

Chapter 62 Urinary Blader

NCCN Guidelines for Bladder Cancer

PRINCIPLES OF SYSTEMIC THERAPY

Neoadjuvant Chemotherapy (preferred for bladder)

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