05-16-2025

Human Papilloma Virus (HPV) Status

**Only required to be coded by SEER STATES

• Path: LEFT TONGUE BASE, BIOPSY (FSA): SQUAMOUS CELL CARCINOMA, NON-KERATINIZING TYPE p16+ immunohistochemical stain is repeated twice and shows a variable staining (60-70%) pattern
  • Supplemental Report
    • HPV RNA ISH Panel: Results:

• High-risk HPV cocktail: DETECTED
• High-risk HPV subtypes 16/18: DETECTED
• Low-risk HPV cocktail: Not Detected

Question: How would the SEER SSF1 Human Papilloma Virus (HPV) Status be coded?

• 11 HPV positive by p16 test
• 21 HPV positive for viral DNA by ISH test
• 31 HPV positive for viral DNA by PCR test
• 41 HPV positive by ISH E6/E7 RNA test
• 51 HPV positive by RT-PCR E6/E7 RNA test
• 71 HPV status reported in medical records as positive, but test type is unknown

Answer & Rationale: 41 HPV positive by ISH E6/E7 RNA test

SEER Site Specific Fact 1 Human Papilloma Virus (HPV) Status

• Note 5: For cases in the Oropharynx HPV-Mediated (p16+) schema
  • If an additional HPV test is done in addition to p16, code those test results in this data item
  • If no additional HPV test is done, code 11 in this data item (Schema Discriminator 2 coded to 2)