Tumor Tips

Tumor Tip of the Week 04-03-2026 To Be Ambiguous or Not To Be Ambiguous

03-27-2026 TURB only-not eligible for AJCC Path Stage

Scenario:

  • 3/7/26 PET Scan: Enlarged Cervical, Mediastinal, Axillary & Mesenteric Adenopathy most compatible with Lymphoproliferative Disorder Such As CLL.
  • 4/3/26 Peripheral Blood: B-Cell Population detected (83% lymphoid cells). Flow cytometry shows monotypic B-Cells with co-expression of CD5. Immunophenotype most consistent with CLL/SLL.

Question: How would you assign the Date of Diagnosis?

  • 03/07/2026
  • 04/03/2026

Answer: 04/03/2026

References

SEER Program Coding and Staging Manual 

  • Ambiguous Terminology
    • Equivalent to “Not diagnostic for” malignancy or reportable diagnosis. These phrases are NOT reportable when no other information is available.
  • Highly suspicious for, but not diagnostic of [malignancy or reportable diagnosis].
  • Most compatible with a [non-reportable diagnosis] such as a [reportable diagnosis].
  • High probability for [malignancy or reportable diagnosis]

SEER Hematopoietic and Lymphoid Neoplasm Database: https://seer.cancer.gov/seertools/hemelymph/

  • Lymphoproliferative Disease, NOS- 9970/1.

SEER Program Coding and Staging Manual

  • Date of Diagnosis
    • Code the month, day, and year the tumor was first diagnosed, clinically or microscopically, by a recognized medical practitioner. Medical practitioner includes physician, physician assistant, nurse practitioner, nurse midwife, residents, fellows, medical trainees, and licensed recognized medical practitioner as determined by a state.
      • When the first diagnosis includes reportable ambiguous terminology, record the date of that diagnosis

Discussion:

The 3/7/26 PET scan described adenopathy suspicious for a lymphoproliferative disorder such as CLL. Lymphoproliferative disorder is a non‑reportable term (/1). Per SEER ambiguous terminology rules, use of an ambiguous term with a non‑reportable diagnosis followed by “such as” a reportable malignancy does not meet reporting criteria.

On 4/3/26, peripheral blood findings were reported as most consistent with CLL/SLL, establishing a definitive diagnosis. Therefore, the case becomes reportable effective 4/3/26.

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